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Ragged Clown's avatar

I went to the White House for a Cancer Moonshot meeting as part of VP Biden’s Cancer Initiative about 12 years ago. About 30 of us sat around a big table for a day and at the end of it, we agreed to have an intern try to improve the API for retrieving clinical trial descriptions. Not that that did much good because pharma companies gain competitive advantage from keeping the important details of their trials secret. That was our moonshot.

It's not all bad news though.

There is unlikely to be a single cure for cancer because cancer is lots of different diseases but targeted therapy and immunotherapy has been close to a miracle for some cancers. Kidney cancer, for example, has gone from practically no treatments to 50% five-year survival over the space of about ten years. Maybe not quite a moon landing yet but they are maybe orbiting the moon. The government rules do their best to thwart the people shooting for the moon with forms filled out in triplicate though.

I have terminal brain cancer and there have been no new treatments for gliomas for about twenty years. There’s a new targeted therapy — vorasedinib — that was so successful that they called an early halt to its phase 3 trials to get it out to real patients in a rush job. It was given Fast Track Designation in February 2023 and should receive actual approval later this year. Fast Track indeed.

There are people shooting for the moon but they are blocked by people with clipboards. It’s all very sad.

> “I gotta laugh at that because otherwise I’d cry.”

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Neil's avatar

Great article. Another in the line of scientists with a great hunch who were howled down by the experts is Ignaz Semmelweis. When it was finally adopted, his radical notion dropped maternal mortality rates from 18% to less than 2% in Vienna General Hospital in 1847. The revolutionary idea which so upset the status quo? Clinicians should disinfect their hands before moving between patients.

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